US Clinicals® StrongImmune Lactoferrin Prevents COVID-19 Infection and Improves Post COVID-19 Recovery

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US Clinicals® StrongImmune Lactoferrin Prevents COVID-19 Infection and Improves Post COVID-19 Recovery

US Clinicals® StrongImmune Lactoferrin Prevents COVID-19 Infection and Improves Post COVID-19 Recovery

In June 2020, a University of Michigan research team had identified Lactoferrin from a library of 1425 FDA-approved compounds that inhibits COVID-19 infection and enhances antiviral host cell responses. [1] Lactoferrin is a protein attained from mammalian milk. It’s known to have powerful antioxidant properties make up a natural barrier against bacterial and viral infections. It also acts as a powerful rein enforcement for immune health.   

 

In a different study, a team of Italian scientists, led by Luigi Rosa from the Department of Public Health and Infectious Diseases, University of Rome, Italy, had published a paper in September 2021 in an MDPI journal that’s known for its pioneer in scholarly open access publishing that’s based in Basel, Switzerland. They claim Lactoferrin (Lf), a glycoprotein found in cow or human milk, can be used in COVID-19 prevention, and helps shorten the negative conversion time after a COVID-19 infection [2].

Human Lactoferrin synthesis is under hormonal control [3] and therefore, diminishes with age. This explains why the elderly suffer from more severe symptoms as opposed to young children and indicates Lactoferrin treatment becomes increasingly effective with age.

The positive side is that bovine lactoferrin (bLf) possesses a high homology of gene sequence with similar functions to human lactoferrin (hLf). Therefore, humans can take bLf supplements orally to increase their Lf levels.   

 

The 2 Ways Lactoferrin Works

Lactoferrin works to prevent COVID 19 infection and improve post COVID-19 recovery. In this article we explore how lactoferrin affects both the cell and the receptor.

 

1) Lactoferrin’s Prevention Capacity

Lactoferrin’s ability to prevent COVID-19 is due to the fact that Lactoferrin hinders viral entry into host cells [3]. Lactoferrin acts as a protective natural barrier between human cells and COVID-19, thus preventing the virus from entering the human body.

Those who are infected with COVID-19, the symptoms start from the respiratory and digestive systems, and eventually more vital organs like blood cells, which causes coagulopathy. Viruses only attack humans by identifying a receptor in the human body called the angiotensin-converting enzyme 2 (ACE2) [3]. In humans, high ACE2 expression is found in the respiratory system epithelial cells (lung, nasal cavity), and the digestive system (oral mucosa, stomach, intestines), as well as heart muscle cells (myocardia), inner blood surface cells (basal endothelial cells), the brain, and hematopoietic cells (inside the spine, to regenerate blood).

On the grounds that COVID-19 is defined by its respiratory and gastrointestinal symptoms, our main concern lies with the question of “what can be done to protect ourselves from being infected through the respiratory and digestive systems?”. The answer could very well be Lactoferrin. LF is a part of the innate immunity which consists of a protein produced by the human body in secretions such as saliva. Hence, LF is transported to the respiratory and digestive systems’ epithelium through secretion, where the COVID-19 viruses are detected via receptor ACE2.

Lactoferrin contains two positively charged irons, which bind with negatively charged epithelial cells. This appears to be a protective coating for the respiratory and digestive systems’ inner cells. As soon as COVID-19 enters the respiratory and digestive systems and touches their inner surfaces, Lactoferrin binds itself to the virus and the ACE2 receptor, blocking the connection between the virus and the cell. Hence, COVID-19 fails to enter the cell.

 

2) Shorten the Negative Conversion Time

As mentioned previously, lactoferrin helps prevent COVID-19 virus from entering cells. However, if there’s insufficient lactoferrin on the inner surface of your airway due to aging or other factors, the virus will penetrate the cell as a result leading to an infection.

At the initial stage of infection, COVID-19 triggers proinflammatory cytokines, which leads to iron homeostasis disorders. The imbalance of iron homeostasis causes an overload of iron ions in the cells. Free iron ions are the “food” of virus, and an iron overload may cause the virus to replicate in large numbers, given that viruses, like human cells, require iron to survive [3]. If this replication happens in vital organs like the brain or blood vessels, more severe symptoms like coagulopathy may occur, which could result in death.

Following an infection, the body is supplied with lactoferrin and as aforementioned, the inner surfaces of the respiratory and digestive systems are protected, preventing new viruses from entering the cell. In a healthy individual, around 30-40% of lactoferrin is iron-coupled, and the remaining 60-70% of lactoferrin is iron-free. As a result, free iron will be absorbed by the 60-70% of lactoferrin that doesn’t contain iron, preventing viral replication and allowing the patient to recover gradually.

Lactoferrin’s anti-viral activity helps restore iron homeostasis by absorbing the free iron triggered by inflammation, causing a reduction in the number of free ions, which in turn inhibits virus replication and growth. Hence, patients experience faster recovery from COVID-19. This has been proven by a study involving 121 Italian patients [2].

According to the previously stated study, lactoferrin-supplemented COVID-19 patients showed significantly faster recovery from clinical symptoms as opposed to COVID-19 patients who were treated with standard of care as well as those who were not supplemented with lactoferrin [2]. From October 2020 to March 2021, the 121 patients infected with COVID-19 revealed that the time required to achieve SARS-CoV-2 RNA negative conversion in Lf-treated patients (n = 82) was 37% shorter (p < 0.001) than in Lf-untreated patients (n = 39) (15 versus 24 days). The discrepancy is more apparent in elderly patients.

 

Lactoferrin Supplement is Safe for Consumption

For several years now, various products containing Lf have been marketed as nutraceutical products. All of these products contain Lf derived from bovine milk (bLf), which possesses a high homology of gene sequence with similar functions to that of human Lf (hLf). Furthermore, bLf has been approved as Generally Recognized as Safe (GRAS) compound by the United States Food and Drug Administration (USA FDA) as well as a dietary supplement by the European Food Safety Authority [1].

US Clinicals® StrongImmune Lactoferrin is a lactoferrin supplement that provides dual action. Unlike other immune booster supplements such as Vitamin C meant solely for basic immune-boosting, our formulation contains Bovine Lactoferrin from New Zealand and Singapore Patented Biosculptor™ Probiotics that’s scientifically proven to enhance gut health and maintain a balance of good bacteria in the gut.

US Clinicals StrongImmune Lactoferrin is a supplement to boost body's defense against viruses.

Product Overview

StrongImmune Lactoferrin:

  • High purity lactoferrin from New Zealand
  • Extracted from grass-fed bovine milk
  • Contains Singapore Patented Biosculptor™ Probiotics
  • Freeze-dry technology - Protects heat sensitive proteins found in Lactoferrin, while maximizing functionality
  • High quality

 

StrongImmune Lactoferrin’s Main Functions:

  • Anti-COVID - Strongly inhibits entry of COVID-19 into cells
  • Post COVID Recovery - Heightens host cells’ innate immune responses to resolve the Gastrointestinal (GI) symptoms that are present in COVID 19 patients

 

Benefits of Singapore Patented Biosculptor™ Probiotics

  • Heighten immune response
  • Promote healthy digestive tract
  • Reduce inflammation

 

When to consume US Clinicals® StrongImmune Lactoferrin:

US Clinicals® StrongImmune Lactoferrin is meant to be consumed daily for protection against potential viruses or if you are having flu or cough. It is also meant to be consumed prior to travelling or attending social gatherings and interactions.

 

Recommended Dosage

Take 1 capsule daily. Consume with food. For children below 12 years old, take half capsule daily. Those who are unable to swallow, open the capsule and mix with food or drinks.

 

References:

  1. Mirabelli, C., Wotring, J. W., Zhang, C. J., McCarty, S. M., Fursmidt, R., Pretto, C. D., Qiao, Y., Zhang, Y., Frum, T., Kadambi, N. S., Amin, A. T., O’Meara, T. R., Spence, J. R., Huang, J., Alysandratos, K. D., Kotton, D. N., Handelman, S. K., Wobus, C. E., Weatherwax, K. J., . . . Sexton, J. Z. (2021). Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proceedings of the National Academy of Sciences, 118(36), e2105815118. https://doi.org/10.1073/pnas.2105815118
  2. Campione, E., Lanna, C., Cosio, T., Rosa, L., Conte, M. P., Iacovelli, F., Romeo, A., Falconi, M., del Vecchio, C., Franchin, E., Lia, M. S., Minieri, M., Chiaramonte, C., Ciotti, M., Nuccetelli, M., Terrinoni, A., Magrini, A., Bernardini, S., Andreoni, M., . . . Bianchi, L. (2020). Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients: in vitro and in vivo preliminary evidences. Published. https://doi.org/10.1101/2020.08.11.244996
  3. Berlutti, F., Pantanella, F., Natalizi, T., Frioni, A., Paesano, R., Polimeni, A., & Valenti, P. (2011). Antiviral Properties of Lactoferrin—A Natural Immunity Molecule. Molecules, 16(8), 6992–7018. https://doi.org/10.3390/molecules16086992

 

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